OUP user menu

Cytokine expression in the liver of mice infected with a highly virulent strain of Francisella tularensis

Igor Golovliov, Kerstin Kuoppa, Anders Sjöstedt, Arne Tärnvik, Gunnar Sandström
DOI: http://dx.doi.org/10.1111/j.1574-695X.1996.tb00244.x 239-244 First published online: 1 March 1996


Cytokine mRNA expression was determined in the liver of mice subcutaneously inoculated with a lethal dose of the highly virulent strain FSC 041 of Francisella tularensis subvar, tularensis or a sublethal dose of the live vaccine strain of F. tularensis subvar, palaearctica. Expression of mRNA for TNF-α, IL-12, IFN-γ, and IL-10 was demonstrated within 48 h of inoculation, the kinetics being similar irrespective of bacterial strain used. Thus, the expression of a cytokine response believed to be important in the early host defence against live vaccine strain seemed insufficient to prevent the lethality of a more virulent strain.

  • Cell-mediated immunity
  • Cytokine expression
  • Francisella tularensis
  • Tularemia